The smart Trick of ceesdekker That No One is Discussing

Working with solitary-molecule optical and AFM imaging and power-spectroscopy strategies, we look for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigate passions contain:

It absolutely was only inside the nineteen nineties however, when nanotechnology had Sophisticated into a degree the place single molecules may very well be manipulated, that the initial experimental equipment began to look.

Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport as a result of a person one-walled carbon nanotube. Depending on low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up authentic quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.

Microbiology has only been around for any century, considering that we began to review micro-organisms extra seriously. I thought nanobiology was an suitable phrase, since all molecular biological pertinent interactions happen with the nanoscale: a protein is some nanometres in dimensions, DNA is two nm thick.’

All parameters ended up a similar for each panel in this video clip, apart from the Preliminary placement on the 6hb rod (revealed in blue) over the nanopore. Simulations that terminated early because of translocation in the rod throughout the pore are marked by a grey track record.

Researching DNA loop extrusion by SMC proteins for chromosome architecture with single-molecule assays.

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Extremely interesting, but that wasn’t really the place my desire lay. I desired to pioneer and I experienced the sensation that was not doable, as the most intriguing elementary insights experienced already been uncovered. But my discipline experienced made numerous interesting new applications to measure personal molecules. I made a decision which i needed to apply this to biology, to look at it from a Bodily viewpoint.’

Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion against roadblock-traversal experiments

Lots of new phenomena have been found, and he and his exploration group founded a leading posture In this particular field of exploration. Dekker and his analysis team identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they have been the first to develop a transistor according to one nanotube molecule.

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It had been an exceedingly intriguing time, through which I cees dekker received plenty of guidance from Delft College of Engineering, wherever I had been a professor at the time, and I started out various collaborations with molecular biologists. That served me discover quite a bit.’